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Extra Strength TYLENOL® Nighttime, 40 caplets

Extra Strength TYLENOL® Nighttime

Extra Strength TYLENOL® Nighttime: The pain relief of TYLENOL®, now with a sleep aid. To help you fall asleep and stay asleep. Have a better night's sleep with Extra Strength TYLENOL® Nighttime.†

When you cannot sleep due to pain, your nights can be a dreadful experience rather than your time to relax and re-charge. The next day, you don’t feel like yourself due to your tiredness. But now there is a trusted solution: †Try Extra Strength TYLENOL® Nighttime to improve the duration of your sleep. Extra Strength TYLENOL® Nighttime contains the pain relief of TYLENOL®, now with a sleep aid. To help you fall asleep and stay asleep.

When you are not suffering from the impact of sleeplessness due to pain, you can GET BACK TO NORMAL, WHATEVER YOUR NORMAL IS®

For effective relief of mild to moderate nighttime pain with accompanying sleeplessness due to:

  • Headaches

  • Backaches

  • Muscle aches and pains

  • Aches and pains due to colds and the flu

Where to buy

  1. Ingredients
  2. Dosage
  3. Caution
  4. Other Information

Active Ingredients:

Purpose

Acetaminophen 500 mg

Pain reliever

Diphenhydramine Hydrochloride 25 mg

Sleep aid


Inactive Ingredients: Carnauba wax, cellulose, corn starch, FD&C blue no. 1 aluminum lake, hypromellose, magnesium stearate, polyethylene glycol, polysorbate 80, sodium citrate, sodium starch glycolate, titanium dioxide.

Uses:

Temporarily relieves mild to moderate nighttime pain with accompanying sleeplessness due to:

  • headaches

  • backaches

  • muscle aches and pains

  • aches and pains due to colds and the flu


Directions:

Do not take more than directed (see liver warnings).

Adult use only (16 years and older):

  • Take 2 caplets at bedtime, or as directed by a doctor.

  • Do not take more than 2 caplets in 24 hours.

  • Read the complete label and insert before use and follow all directions

Warnings: Liver warning: Acetaminophen may cause severe or possibly fatal liver damage if you take:

  • more than the recommended dose in 24 hours

  • with other drugs containing acetaminophen

  • while drinking 3 or more alcoholic drinks every day.

Symptoms of liver damage may include:

  • yellow skin or eyes

  • dark urine

  • sweating

  • nausea

  • vomiting

  • stomach pain

  • unusual tiredness

  • loss of appetite

Allergy alert: Acetaminophen may cause serious skin reactions. Symptoms may include:

  • skin reddening

  • blisters

  • rash.

If any of these symptoms occur, stop use and seek medical help right away.

Do not use

  • with any other drug containing acetaminophen or diphenhydramine, even one used on the skin

  • if allergic to acetaminophen or diphenhydramine or any other ingredient in this product. If you are not sure whether a drug contains acetaminophen or diphenhydramine, ask a doctor or pharmacist

Ask a doctor or pharmacist before use if you

  • have liver or kidney disease

  • are on any other medication including the blood thinning drug warfarin, sedatives or tranquilizers

  • have glaucoma

  • difficulty urinating due to an enlarged prostate

  • chronic lung disease (including asthma, emphysema or chronic bronchitis)

  • are elderly, as this drug may cause excitation rather than sedation

  • are pregnant or breastfeeding

When using this product

  • avoid alcohol

  • drowsiness or dizziness may occur

  • do not drive a motor vehicle, operate machinery or engage in activities requiring alertness. Alcohol, sedatives and tranquilizers may increase drowsiness.

Stop use and ask a doctor if

  • sleeplessness due to mild to moderate pain lasts for more than 5 days, if new symptoms appear or existing symptoms worsen. Sleeplessness may be a symptom of serious underlying medical illness.

KEEP OUT OF THE REACH OF CHILDREN. This package contains enough drug to seriously harm a child.

In Case of Overdose: Call a Poison Control Centre or get medical help right away. Quick medical attention is critical even if you do not notice any signs or symptoms.

  • Do not use if carton is open or inner foil seal is missing or broken

  • Child resistant package

  • Store at 15 to 30°C

  • Not a standard dosage unit product

  • Use only on the advice of a doctor

This website contains product information and may differ from the information on the product packaging you may have. Please refer to your product package for the most up to date product information.

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© Kenvue Canada Inc. 2025. All rights reserved. This website is intended for visitors from Canada. The third-party trademarks used herein are trademarks of their respective owners. Be sure this product is right for you. Always read and follow the label.

Please note that this content is not intended as professional medical or healthcare advice and is not intended as a substitute for professional healthcare advice, or services from a qualified healthcare provider such as a physician, pediatrician or other professional familiar with your unique situation. This content is intended solely as a general product and educational aid. If you have any questions, please consult your physician or pharmacist.

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